Heidelberg edge perimetry and retinal tomography in diagnosis of initial open-angle glaucoma

The purpose of the study is to develop an algorithm that increases the accuracy of diagnosing initial open-angle glaucoma using Heidelberg edge perimetry and retinal tomography. Material and Methods. The study involved 624 patients (624 eyes): 236 males and 388 females. The mean age was 63.4±9.3 years old. All patients underwent routine ophthalmic examination, Heidelberg edge perimetry (HEP), and Heidelberg retinal tomography (HRT) depending on the results achieved. Results. The study revealed both direct and inverse relationships between the disease and particular HRT parameters. We established quantitative characteristics of the optic disc parameters, where pathological alterations were revealed receiver operating curve (ROC-analysis) mathematical method. We analyzed the data from the positions of attribution of a patient's individual parameters to the risk factor according to the received cut-off point limit values. Seven main parameters, which received the best evaluation of diagnostic informativity according to ROC-analysis, were assessed. Then we compared the number of risk factors and the real value of the sick/healthy characteristic. Conclusion. We have developed a new algorithm to diagnose the initial open-angle glaucoma. According to this algorithm, the most applicable diagnostic practice is to set the diagnosis in the presence of five risk factors in the individual optic disc values with 95% specificity.