Hemocoagulation and lipid peroxidation in women who has been taking steroids with ethinylestradiol and progestogens

Blood coagulopotential and lipidperoxydation (LPO) after each cycle were estimated in 120 women of 18-45 years old who use combined oral contraceptivs (COCs) of ethinyl estradiol (30 mcg) and desogestrel (150 mcg), or ethinylestradiol (30 mg) and dienogest (2 mg) 12 cycles for 21 days with a 7-day break. It was found that COCs containing ethinylestradiol with a third-generation progestogen increase blood clotting accelerate LPO in the blood and reduce its antioxidant activity. Significant shifts are noticed in the use of SRI dienogest. It is necessary to continue to study the mechanisms of these shifts in the hormone contraception, comparing the effects of known progestogens and using antioxidants for the correction.