Genetically determined thrombophilia in childhood

The article presents a review of the medical sources devoted to hereditary thrombophilia in children. So far, there is no consensus on the contribution of genetic thrombophilia to the development of thrombosis in children. The analysis of published data shows that thrombosis in children increases the incidence of defective genes with thrombophilia: Leiden mutation, prothrombin mutation, C677T polymorphism in the gene for methylenetetrahy drofolatereductases polymorphism 4G/5G gene of inhibitor-1 plasminogene, which is accompanied with an increased risk of thrombosis.