Genetic aspects of electrical remodeling of the heart in patients with arterial hypertension

During this work, a comprehensive assessment of changes in the electrophysiological features of cardiac parameters in patients with arterial hypertension depending on the type of gene polymorphisms of the rennin angiotensine system. According to the results of the present study we found that the processes of electrophysiological remodeling of the heart affect patterns of genetic polymorphism of the rennin angiotensine system. The presence of D-allele of the ACE gene and allele genotype AT2R1 hypertensive patients are accompanied by increasing heterogeneity of electrical processes in the myocardium of the atria and ventricles, increasing frequency of late potentials registration, clinical manifestations which are the arterial and ventricular premature beats. Ventricular arrhythmia associated with high-grade C-alleles AT2R1.