Genetic risk factors in development of acute brain ischemia in young and middle aged patients

By studying of genetic polymorphism of hemostasis system associated with increased risk of thrombophilia in young and middle age patients with ischemic stroke, analysis of genetic risk factors of acute brain ischemia was carried out. Polymorphisms of candidate genes of ischemic lesion described in literature: gene FII mutation 20210G>A, gene FV mutation 1691G>A, gene FVII mutation 10976G>A, gene FGB mutation -455G>A, gene PAI-1 mutation -675 5G>4G, gene ITGA2 mutation 807C>T, gene ITGB3 mutation 1565Т>С were selected for research. Concluded that genetic susceptibility to thrombophilic conditions plays a large role in ischemic stroke in young and middle age patients. Data analysis revealed statistically significant prevalence of mutant alleles in genes FBG, PAI-1, FV.