Genetic traits of teenage abdominal obesity in the city of Samara

Metabolic syndrome is a group of metabolic risk factors including dyslipidemia, carbohydrate intolerance, arterial hypertension and abdominal obesity. It is known that leptin participates in energy homeostasis. The object of the work was to study leptin concentration and biochemical values in obese and normal and to identify the relation of leptin receptor gene (LEPR) Gln223Arg polymorphism to blood leptin concentration and metabolic disorders in Samara school children. The methods were as follows: the study was carried out among 125 students (including 100 obese children and 25 normal children who were a control group). The indices which were studied are leptin, insulin, glucose and lipid values. LEPR Gln223Arg genotyping was performed using the method of polymerase chain reaction. The results were as follows: The obese children had higher leptin values in their blood serum than the children of the control group (р