Genetic predicts of ischemic stroke (a clinical case of a child's ischemic stroke)

Acute disorders of cerebral circulation present one of the most topical medical-social problems, since in Russia according to various data the level of incapacitation after a previous stroke amounts to 76 to 85 %. According to a number of authors the development of such cardiovascular diseases as coronary heart disease and brain ischemia is determined by complex interaction of external factors with genetic features of an individual's metabolism. In this connection, practical application of knowledge-intensive methods of diagnostics, which allow identifying pathology at the stage of pre-existing disease, is a really pressing problem. Identifying «risk genes» and searching for genome loci that create a disposition to various diseases including cerebral circulation disorders form the basis for development of predictive medicine, which allows selecting patients and breaking them up into risk groups in order to use brand new methods of treatment and disease prevention. The article presents a case of ischemic stroke in a child. The laboratory study data clearly demonstrate the relevancy of using genetic testing for the purpose of identifying genes that are pre-disposed to the development of ischemic stroke. These data also demonstrate the feasibility of starting targeted, pathogenetically justified therapy, as well as prevention of backsets of the disease.