Genetic polymorphism of toll-like receptor 6 in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic in ammatory disease susceptibility to which is determined by complex multifactorial interactions of genetic and environmental factors. According to scienti c data, TLRs are involved in the immunopathogenesis of autoimmune pathologies such as rheumatoid arthritis. Polymorphism of tolllike receptors genes leads to disturbances in the expression of these receptors, a decrease in functions and failures of the body’s defense reactions. Aim: analysis of the distribution of allelic variants and genotypes of SNP 745C>T TLR6 in patients with rheumatoid arthritis of the Russian population of the Chelyabinsk region. Thus, the study shows the signi cance of the SNP Pro249Ser polymorphism in the TLR6 gene for the occurrence of predisposition to rheumatoid arthritis in Russians from the Chelyabinsk region. Research methods: DNA extraction, allele-speci c PCR with electrophoretic detection of results. Statistical processing was carried out using generally accepted approaches in immunogenetic studies. The research shows that in the group of RA patients, the frequencies of the allele with a replacement and its homozygous genotype are increased. The conducted study shows the signi cance of the SNP Pro249Ser polymorphism in the TLR6 gene for the occurrence of predisposition to rheumatoid arthritis in Russians from the Chelyabinsk region.