Genetics and epigenetics of Alzheimer's disease: new cognitive technologies and neurocommunication

The 21st century Homo sapiens evolves and improves using new nano, bio, information and cognitive technologies that provide and focus on cognitive and creative processes. 21st century brain H. sapiens combines internal and external layered information into a single algorithm for structuring, routing, storing, and retrieving information in the present and future time period. 4P and 5P medicine, 5G medical services, next-generation sequencing and pharmacogenetics are new modern foundations of personalized medicine. The next-generation information and communication infrastructure of 5G for clients (patients) from the medical sphere is an intelligent border-cloud platform with an integrated cloud network architecture. Next-generation mobile technologies are being introduced in a modern hospital: from higher communication speeds to smart computing and additional reality. 5G medical services are a revolution in the medical industry. Neuromarketing and neurobytes, neuroimaging of consciousness and brain-machine interfaces, biorobots and biochips interact with the “external and internal hippocampus”. The result of human activity in a market economy and a new society is intellectual property. The heterogeneous nature of dementia (Alzheimer’s disease, Peak, frontal-temporal degeneration) and the various pathophysiological features of specific dementia highlight the need to develop separate algorithms based on current biomarkers specific to these diseases. Modern prognosis of Alzheimer’s disease is achieved by structural neuroimaging, cognitive testing, and biological indicators (genotype APOE-ε4) based, both on orders, standards, and clinical recommendations, as well as on the quantitative assessment of brain structures using neurointerfaces. The functioning of integrated neural systems through integration and analysis of dynamic hybrid multimodal neural EEG and fMRI information, combined with neuropsychological testing, will enable the geriatric clinician to manage healthy aging of H. sapiens .