Sodium hypochlorite and partial functions of the kidneysin the experiment and in patients with urolithiasis and renal insufficiency

Study of the influence of sodium hypochlorite (SH) on the amount of the excreted fraction of filtered sodium in the experiment and in patients of the urological clinic with urolithiasis and chronic renal failure (CRF). The experimental part of the work was performed on 15 white mongrel rats weighing 160-260 grams. The clinical part of the study was carried out in three groups of patients with urolithiasis complicated by the development of CRF in the latent, compensated and terminal stages. All patients underwent indirect electrochemical blood oxidation (IEBO) sessions with 0.06% solution of SH at a dose of 2.0-3.0 mg / kg / day. The dynamics of the excreted fraction of filtered sodium was studied. As a result of the conducted experiment on animals it was possible to prove the presence of a dose-dependent effect of SH on the functional capacity of the renal tubules. The metabolic effect of the systemic action of SH with IEBO was most effective in the group of patients with compensated stage chronic renal insufficiency...