Lipid-lowering and pleiotropic effects of statins in patients with osteoarthritis and metabolic syndrome

In the course of work was assessed the influence of atorvastatin on the dynamics of indices of lipid spectrum of blood, indicators of inflammatory activity and intensity of pain among patients with osteoarthritis and metabolic syndrome. The results of the study found that at 12 months among patients in the study group treated with atorvastatin, there was marked improvement in all lipid levels, reduction in ESR, CRP and TNF-α, significant decrease in the intensity of the manifestations of pain syndrome at rest and during movement, and reduced the severity of articular manifestations according to the WOMAC and Lequesne indices compared with the control group patients.