Histological characteristics of rete ovarii in acute period of genital herpes virus infection

Structural and functional states of the rete ovarii were investigated in healthy mature females Guinea pigs and Guinea pigs during the acute phase of genital herpes virus infection. The methods of light and transmission electron microscopy, immunohistochemical analysis of alpha-receptors to estrogenes, immunofluorescence studies of herpes simplex virus antigens, quantitative morphometry were used. In the acute phase of genital herpes infection all animals had the multi cystic transformation of the rete ovarii in the background of overt signs of inflammation in the medulla of the ovaries; also a decrease in the activity of immunohistochemical labelling of nuclei of epithelial cells of the rete ovarii to the alpha-receptor of estrogenes and immunofluorescent staining of the nuclei of these cells to the virus antigens was registered. Therefore negative effects of the herpes simplex virus on the regulatory effects of estrogenes and morphophysiology of rete ovarii with the outcome in cystic transformation were showed.