Hormonal-methabolic characteristics in patients with endometrial hyperplasia and endometrial cancer

Hormonal and energetic status was studied in 138 patients with endometrial hyperplasia and endometrial cancer. The comparative analysis of hormonal status (LH, FSH, estrogen, progesterone, testosterone, prolactin, SHBG), energetic status (leptin, grelin, insulin) and the assessment of lipid and carbohydrate metabolisms were carried out for patients with proliferative processes in the endometrium with the evidence of metabolic syndrome and without it. The study showed that the changes in hormonal status were characterized by a high frequency of disturbances with development of hyperestrogenemia (72 %), hypertestosteronemia (65 %), hyperinsulinemia (81 %) and hyperleptinemia (68 %). Moreover, the LH level and LH/FSH index were increased and FSH and progerterone levels were decreased. Significant changes in both carbohydrate (hyperinsulinemia, insulin resistance) and lipid (hypercholesterolemia, hypertriglyceridemia) metabolisms were revealed. Mechanisms of hormonal correlations which uderlie pathological endometrial process were suggested. Further investigations are required to individually prognosticate endometrial cancer process and to form the groups at high risk for endometrial cancer based on the assessment of hormonal and energetic balances, as well as to correct properly metabolic disorders in patients with endometrial hyperplasia and endometrial cancer.