Changes in the cerebral cortex neuron ultrastructure in rats with partial cerebral ischemia

The ultrastructural characteristics of neuronal organelles are significant indicators of brain damage under ischemic exposure, which necessitates the study of changes in the ultrastructure of brain neurons. The aim of the study was to examine the disorders of brain neurons under its partial ischemia at the ultra-structural level using an experimental model. Materials and Methods. The experimental group included 12 male rats weighing 260±20 g, the control group consisted of 6 falsely operated male rats of the same weight. Partial cerebral ischemia (PCI) was modeled by right common carotid artery ligation. The material was taken 1 hour after the operation. Results. The study showed that the size and shape of the mitochondria of neurons of the parietal cortex and the hippocampus in PCI rats did not differ from those of the control group (p>0.05), except for a smaller number of cristae per unit area in the mitochondria of parietal cortex neurons (by 18 %, p