Characteristics of prolifeartion marker expression and apoptosis regulation depending on the character of disregenerator changes in bronchial epithelium of patients with squamous cell lung cancer

Tissue specimens of the removed lung outside the tumor were histologically studied from 49 patients operated on for squamous cell lung cancer. Microscopic examination revealed various disregeneration changes. Factors reflecting the level of proliferative activity and participating in apoptosis (Ki67, p53, bcl-2) in evaluation of hyperplastic, pereneoplastic and neoplastic changes in bronchial epithelium were studied. The increase in the number of cells expressing Ki67, p53 and bcl-2 in sequential progression: basal hyperplasia - squamous methaplasia - dysplasia I (preneoplasia) - dysplasia II-III (neoplasia) was not shown to depend on individual characteristics because it was observed in combination with various forms of disregeneration changes in bronchial epithelium of the patient.