Characteristics of acute toxicity of OMEC mineral top dressing

The research was carried out in the conditions of the Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilov. The experimental samples of mineral top dressing were made using the technical base by the company Bioamide CJSC (Russia). To carry out the experimental part of the work, 40 white rats weighing 200-230 grams each were selected, subsequently, using the method of paired analogies groups were formed, including ten individuals each. The white rats of the control group were not given mineral top dressing "OMEC". The drug "OMEC" was used in its native form. The test substance was administered to experimental rats intraperitoneally in recommended therapeutic doses (165, 231 and 452 mg / kg), which were calculated according to the active substance of the drug. Also, in order to obtain reliable experimental results, individuals of the control group were injected once intraperitoneally in the maximum permissible volume (5 ml) of water for injection. The characteristics of acute toxicity of the studied mineral composition were studied according to certain criteria accepted in veterinary medicine: the strength and frequency of motor activity, appetite and thirst, the response of experienced rats to sound stimuli and light, the possibility of neurological disorders, including paresis and convulsions of individual muscle groups, changes in coordination, the state of visible mucous membranes and hair, the dynamics of body weight. The observations were carried out according to strict regulations for 14 days. The tested doses of the mineral preparation did not lead to deviations in the kinetics of body weight gain in rats. The increase in the live weight of the experimental rats was 115,3±1,2; 115,7±1,1; 114,8±0,93% compared with the reference value of 112.73±1.21 to the submitted indicator. The administration of the test drug in therapeutic doses did not cause fatal outcomes in rats.