Characteristics of free radical lipid peroxidation and its connection with iron exchange in experimental hepatitis therapy

The purpose of the work is to study the processes of free radical lipid peroxidation, antioxidant system activity and their connection with the iron metabolism in white rats with experimental hepatitis, and after the use of hepatoprotectors. Materials and Methods. Studies were conducted on white Wistar rats: body weight - 180-200 g, age -3 months. "Berlition" and "Legalon M" were administered intramuscularly, 0.2 ml per animal once a day (30 days). The authors registered the content of malonic dialdehyde (MDA), diene conjugates, cata-lase activity, serum iron level, total and unsaturated iron binding capacity. Results. In experimental animals, the level of diene conjugates increased 1.8 times if compared with healthy ones. After the administration of "Legalon M" and "Berlition", the concentration of diene conjugates decreased by 58.6 % (by half) compared with the experimental animals. It was established that the malondialdehyde content significantly increased in all tissues...