Chemoradiation therapy with the use of inhomogeneous daily dose distribution for patients with oral cavity and oropharyngeal cancer

The efficacy of conservative treatment of 188 patients with histologically-verified primary oral cavity and oropharyngeal cancer was analyzed. Two treatment methods were used: the conventional radiation therapy (2 Gy, 5 times a week) and chemoradiation therapy (dose fractions of 1 Gy + 1,5 Gy with 4-6-hour interval) up to a total dose of 60 Gy. The data obtained showed that chemoradiation therapy was more effective than the standard radiation therapy with regard to objective responses and complete tumor regressions. The rate of objective responses (the sum of complete and partial regressions) was 97,8 % after chemoradiation therapy and 61,9 % after the conventional radiation therapy (p