Histological and hormonal study of the protective effect of the Calotropis procera against the toxicity of mercury chloride

Histological and hormonal study of the protective effect of the Calotropis procera against the toxicity of mercury chloride

Автор: Belfarhi Leila, Chouba Ibtissem, Amri Naziha, Boukris Nadia, Tahraoui Abdelkrim

Журнал: Природные системы и ресурсы @ns-jvolsu

Рубрика: Экология и биология

Статья в выпуске: 2 т.10, 2020 года.

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We undertook this study with the aim of investigating the detoxification of an extreme toxic metalmercury chloride by the Calotropis procera plant taken from the Algerian Sahara. We studied the protective effectsof the plant Calotropis procera against renal toxicity and Mercury chloride-induced hepatic. Ten male and femalealbino rats Wistar were divided into four equal groups. Group (I) served as a healthy control group, group (II) wereintra-peritoneal administered with 10 ml of Calotropis procera, group (III) were intra-peritoneal administrated withboth 10 ml of the plant Calotropis procera and 0.2 mg of mercuric chloride (HgCl2) and group (IV) were intra-peritoneal administrated with both 0.2 mg of mercuric chlorid (HgCl2) and 10 ml of the plant Calotropis. All groupswere treated for 20 days. Mercury chloride causes a slight increase in glomerular cellularitis in the kidneys of maleand female rats. Treatment with Calotropis procera had significantly improving protective effects of kidney offemale rats from toxicity of mercuric chloride. Calotropis procera causes a thyroid-like appearance in the glomeruliof the male kidneys to hide the lesions of mercury chloride. Our results have shown that the plant Calotropisprocera completely protects the liver of female rats against the toxicity of mercury chloride. In the liver of male rats,mercury chloride causes macro-vacuolar steatosis. Treatment with Calotrpois procera hid the hepatic steatosis ofmale rats and centralized them in the center under the aspect of peri-centro-lobular medio-vacuolar steatosis.Mercuric chloride caused a decrease in the secretion of the hormone ACTH in the group of male and female rats.Treatment with Calotropis procera caused increased ACTH levels in female rats and did not cause ACTH changesin male rats. Our results demonstrate from hormone analyzes of the hormone ACTH that female rats are resistantmore than male rats via the toxicity of mercury chloride.

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Mercury, acth, histology, kidney, liver, glomerular cellularity, discrete lesion, thyroid-like condition

Короткий адрес: https://sciup.org/149131478

IDR: 149131478   |   DOI: 10.15688/nsr.jvolsu.2020.2.1

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