Choleretic activity of the extract from Hedysarum alpinum L. at intact rats

A necessity in finding new hepatoprotective drugs and supplements is dictated by the growing demand: increasingly widespread liver pathologies tending to chronic forms being caused by viruses, toxic agents including some medication. Vegetable raw materials - alpine penny grass was harvested during flowering in the Baikal region in 2020-2021. The collected raw materials corresponded to VFS 42-1998-85 "Penny grass." A dry extract from this raw material was obtained by alcohol-water extraction. The obtained extract contained flavonoids, xanthones, polysaccharides and other biologically active substances in significant amounts. Experiments were carried out on white male rats of the Wistar line weighing 170-200 g. In experiments on white rats, pronounced choleretic activity of the extract of dry hedysarum alpinum L. was established at doses of 50-300 mg/kg. In addition, the resulting penny extract has a beneficial effect on the biochemical composition of bile.