Chromosomal aberrations in gastric tissues of patients with chronic erosive gastritis as a potential marker of early malignant transformation

Molecular-cytogenetic characteristics of gastric tissues were studied in 10 patients with chronic erosive gastritis. Chromosomal abnormalities were detected in 8 patients. Amplifications at 3p12-23 (37,5 %) with minimal overlapping regions 3p14 and 3p22 as well as 3q13.1-27 (37,5 %) with common regions 3q25-26.2 and 3q26.1 were the most common abnormalities followed by amplifications at 2p12-23 (25 %) with minimal regions 2p16; 2q14.1-32 (25 %) with minimal common region 2q31; 4q24-25 (25 %) with minimal overlapping region 4q25 as well as amplifications at 6q21 (25 %) and 6q22-24 (25 %). Furthermore, in one of the cases (№ 7), a trisomy of chromosome 19 was detected. The fact of the presence of high level of unbalanced chromosomal aberrations deserves great attention as a factor associated with development of dysplastic changes.