Chronobiological peculiarities of manifestation and therapeutic dynamics of circular depressions and factor of seasonality

67 patients have been studied (F31.3-31.4, F32.0-32.2, F33.0-33.2). Mean age 46. 7+1,4 years. Therapy was carried out with citalopram or mirtazapin. Depending on season the patients have been divided into two groups: group 1 (autumn-winter depression) - 38 patients and group 2 (spring-summer depression) - 29 patients. To assess variability of heart rhythm spectral analysis has been used. Patients were examined at 1 a. m., 7 a. m., 1 p. m., 7 p. m. prior to the beginning of treatment, following one week, following three weeks and upon leaving the in-patient department. The control group consisted of 15 mentally healthy people (mean age 44,9+2,4 years). At the beginning stage the phase shift to earlier time was more pronounced in spring-summer. Following the first week of treatment features of resynchronization appeared in the day hours (in autumn-winter they weren't). At discharge resynchronization of the rhythms under study was more complete in spring-summer.