Хронодиагностика и хронотерапия - основа персонализированной медицины

Автор: Губин Денис

Журнал: Тюменский медицинский журнал @tmjournal

Статья в выпуске: 1 т.21, 2019 года.

Бесплатный доступ

В современных реалиях игнорирование фактора времени при диагностике и лечении заболеваний становится анахронизмом. Большинство функционально важных генов проявляет циркадную (околосуточную) ритмичность на всех этапах экспрессии. Как следствие существование выраженной суточной динамики большинства клинических показателей означает одно - незнание, или непонимание закономерностей суточной динамики неизбежно будет приводить к неверной интерпретации результатов и высокой частоте ошибок диагностики. Кроме того, динамика физиологических показателей при развитии патологии изменяется, в различной степени утрачивая свою регулярность. Особый интерес для развития методов хронодиагностики представляют исследования амплитудно-фазовых параметров циркадного ритма. С другой стороны, время назначения препарата или иного терапевтического, либо профилактического воздействия может критически влиять на его результат. Определяющими условиями для трансляции фундаментальных знаний хронобиологии в практическое здравоохранение (хрономедицину) являются: 1). Разработка универсальных критериев методологии сбора, анализа и интерпретации результатов динамических наблюдений и 2). Разработка простого, но точного метода оценки фазы биологических часов (фазы эндогенного циркадного ритма). В данной работе проведен сравнительный анализ существующих методов оценки фазы циркадианного ритма и рассмотрены перспективы реализации тактики персонализированной хронодиагностики и хронотерапии.

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Суточный ритм, циркадианный, циркадный, биологические часы, диагностика, терапия, персонализированная медицина, хронотип, фаза, амплитуда, циркадный фенотип, синхронизация, десинхроноз

Короткий адрес: https://sciup.org/140244776

IDR: 140244776 | DOI: 10.36361/2307-4698-2019-21-1-20-40

Список литературы Хронодиагностика и хронотерапия - основа персонализированной медицины

Aho V, Ollila HM, Kronholm E, et al. Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Sci Rep. 2016; 6:24828.
Agostinelli F, Ceglia N, Shahbaba B, Sassone-Corsi P, Baldi P. What time is it? Deep learning approaches for circadian rhythms [published correction appears in Bioinformatics. 2016 Oct 1;32 (19):3051]. Bioinformatics. 2016;32 (12): i8-i17. DOI: 10.1093/bioinformatics/btw243
Akashi M, Soma H, Yamamoto T, et al. Noninvasive method for assessing the human circadian clock using hair follicle cells. Proc Natl Acad Sci USA. 2010;107 (35):15643-15648. DOI: 10.1073/pnas.1003878107
al Enezi J, Revell V, Brown T, et al. A "melanopic" spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights. J. Biol.Rhythms. 2011; 26 (4):314-323.
Albrecht U. Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks. Neuron. 2012. 74: 246-260.
Allebrandt K. V., Teder-Laving M., Kantermann T. et al. Chronotype and sleep duration: the influence of season of assessment. Chronobiol Int. 2014; 31 (5):731-40.
Anafi RC, Francey LJ, Hogenesch JB, Kim J. CYCLOPS reveals human transcriptional rhythms in health and disease. Proc Natl Acad Sci USA. 2017;114 (20):5312-5317.
DOI: 10.1073/pnas.1619320114
Archer SN, Viola AU, Kyriakopoulou V, von Schantz M, Dijk DJ. Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. sleep. 2008;31 (5):608-617.
DOI: 10.1093/sleep/31.5.608
Archer SN, Laing EE, Möller-Levet CS, et al. Mistimed sleep disrupts circadian regulation of the human transcriptome. Proc Natl Acad Sci USA. 2014;111 (6): E682-E691.
DOI: 10.1073/pnas.1316335111
Ashok Kumar PV, Dakup PP, Sarkar S., et al. It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes. Yale J Biol Med. 2019;92 (2):305-316. Published 2019 Jun 27.
Barrett RK, Takahashi JS. Temperature compensation and temperature entrainment of the chick pineal cell circadian clock. J Neurosci. 1995; 15 (8):5681-92.
Basnet S, Merikanto I, Lahti T, et al. Seasonality, morningness-eveningness, and sleep in common non - communicable medical conditions and chronic diseases in a population. Sleep Sci. 2018; 11 (2):85-91.
DOI: 10.5935/1984-0063.20180017
Bass J., Takahashi J. B. Circadian integration of metabolism and energetics. Science. 2010; 330. 6009: 1349-1354.
Bhattacharjee S, Haldar P, Gopal Maity S, et al. Prevalence and Risk Factors of Asthma and Allergy-Related Diseases among Adolescents (PERFORMANCE) study: rationale and methods. ERJ Open Res. 2018;4 (2):00034-2018. Published 2018 Jun 27.
DOI: 10.1183/23120541.00034-2018
Bjarnason GA, Jordan RC, Wood PA, et al. Circadian expression of clock genes in human oral mucosa and skin: association with specific cell-cycle phases. Am J Pathol. 2001;158 (5):1793-1801. 10.1016/S0002-9440 (10) 64135-1.
DOI: 10.1016/S0002-9440(10)64135-1
Bonmati-Carrion MA, Arguelles-Prieto R, Martinez-Madrid MJ, et al. Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure. Slominski A, ed. Int. J. Mol. Sci. 2014; 15 (12):23448-23500.
Borisenkov M. F., Perminova E. V., Kosova A. L. Chronotype, sleep length, and school achievement of 11-to 23-year-old students in northern european Russia. Chronobiology Int. 2010; 27:1259-1270.
Bourguignon C, Storch KF. Control of Rest: Activity by a Dopaminergic Ultradian Oscillator and the Circadian Clock. Front Neurol. 2017; 8:614. Published 2017 Nov 27.
DOI: 10.3389/fneur.2017.00614
Bozek K, Relógio A, Kielbasa SM, et al. Regulation of clock-controlled genes in mammals. PLoS One. 2009;4 (3): e4882.
DOI: 10.1371/journal.pone.0004882
Brancaccio M, Patton AP, Chesham JE, Maywood ES, Hastings MH. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron. 2017; 93 (6):1420-1435.e5.
DOI: 10.1016/j.neuron.2017.02.030
Braun R, Kath WL, Iwanaszko M, et al. Universal method for robust detection of circadian state from gene expression. Proc Natl Acad Sci USA. 2018;115 (39): E9247-E9256.)
Buhr E. D., Yoo S. H., Takahashi J. S. Temperature as a universal resetting cue for mammalian circadian oscillators. Science. 2010. 330: 379-385.
Buhr ED, Takahashi JS. Molecular components of the Mammalian circadian clock. Handb Exp Pharmacol. 2013; (217):3-27.
DOI: 10.1007/978-3-642-25950-0_1
Burioka N, Fukuoka Y, Koyanagi S, et al. Asthma: Chronopharmacotherapy and the molecular clock. Adv Drug Deliv Rev. 2010 Jul 31;62 (9-10):946-55. Epub 2010 Mar 30.
DOI: 10.1016/j.addr.2010.03.012
Burish MJ, Chen Z., Yoo SH. Emerging relevance of circadian rhythms in headaches and neuropathic pain. Acta Physiol (Oxf). 2019 Jan;225 (1): e13161. Epub 2018 Jul 25.
DOI: 10.1111/apha.13161
Cambras T, Weller JR, Anglès-Pujoràs M, et al. Circadian desynchronization of core body temperature and sleep stages in the rat. Proc Natl Acad Sci USA. 2007; 104 (18):7634-7639.
DOI: 10.1073/pnas.0702424104
Carroll R, Metcalfe C, Gunnell D, Mohamed F, Eddleston M. Diurnal variation in probability of death following self-poisoning in Sri Lanka - evidence for chronotoxicity in humans. Int J Epidemiol. 2012 Dec;41 (6):1821-8. Epub 2012 Nov 23.
DOI: 10.1093/ije/dys191
Cespedes Feliciano EM., Quante M., Weng J. et al. Actigraphy-Derived Daily Rest-Activity Patterns and Body Mass Index in Community-Dwelling Adults. Sleep. 2017 Dec 1;40 (12).
DOI: 10.1093/sleep/zsx168
Chakrabarti S, Paek AL, Reyes J. et al. Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages. Nat Commun. 2018;9 (1):5372. Published 2018 Dec 18.
DOI: 10.1038/s41467-018-07788-5
Chen JM, Huang CQ, Ai M, Kuang L. Circadian rhythm of TSH levels in subjects with Alzheimer's disease (AD). Aging Clin Exp Res. 2013 May;25 (2):153-7. Epub 2013 Apr 13.
DOI: 10.1007/s40520-013-0025-x
Chi-Castañeda D, Ortega A. Glial Cells in the Genesis and Regulation of Circadian Rhythms. Front Physiol. 2018; 9:88. Published 2018 Feb 12. 10.3389/fphys.2018. 00088.
DOI: 10.3389/fphys.2018.00088
Cordina-Duverger E., Menegaux F., Popa A. et al. Night shift work and breast cancer: a pooled analysis of population-based case-control studies with complete work history. Eur J Epidemiol. 2018 Apr;33 (4):369-379. Epub 2018 Feb 20.
DOI: 10.1007/s10654-018-0368-x
Cornélissen G, Delcourt A, Toussaint G, et al. Opportunity of detecting pre-hypertension: worldwide data on blood pressure overswinging. Biomed Pharmacother. 2005;59 Suppl 1 (Suppl 1): S152-S157.
Cornelissen G. Cosinor-based rhythmometry. Theor. Biol. Med Model. 2014. 11:16.
Cornelissen G., Watanabe Y., Siegelova J., et al. Chronobiologically interpreted ambulatory blood pressure monitoring: past, present, and future. Biol Rhythm Res. 2019. 50 (1):46-62
DOI: 10.1080/09291016.2018.1491193
Crnko S., Du Pré BC., Sluijter JPG., Van Laake LW. Circadian rhythms and the molecular clock in cardiovascular biology and disease. Nat Rev Cardiol. 2019 Jul;16 (7):437-447.
DOI: 10.1038/s41569-019-0167-4
Daan S. Colin Pittendrigh, Jurgen Aschoff, and the natural entrainment of circadian systems. J Biol. Rhythms. 2000; 15:195-207.
Dakup PP, Porter KI, Little AA, et al. The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models. Oncotarget. 2018 Feb 20;9 (18):14524-14538. 10.18632/Oncotarget.24539. eCollection 2018 Mar 6.
DOI: 10.18632/oncotarget.24539.eCollection2018Mar6
Dallmann R., Viola A. U., Tarokh L., Cajochen C., Brown S. A. The human circadian metabolome. Proc. Natl. Acad. Sci. USA. 2012; 109:2625-2629.
DOI: 10.1073/pnas.1114410109
Dibner C., Schibler U., Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol. 2010; 72:517-49.
Davies SK, Ang JE, Revell VL, et al. Effect of sleep deprivation on the human metabolome. Proc Natl Acad Sci USA. 2014;111 (29):10761-10766.
Deaver JA, Eum SY, Toborek M. Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition. Front Microbiol. 2018; 9:737. Published 2018 Apr 13.
DOI: 10.3389/fmicb.2018.00737
Di Stefano A, Scatà M, Vijayakumar S, Angione C, La Corte A, Liò P. Social dynamics modeling of chrono-nutrition. PLoS Comput Biol. 2019;15 (1): e1006714. Published 2019 Jan 30.
DOI: 10.1371/journal.pcbi.1006714
Douma LG, Gumz ML. Circadian clock-mediated regulation of blood pressure. Free Radic Biol Med. 2018; 119:108-114.
DOI: 10.1016/j.freeradbiomed.2017.11.024
Dupont Rocher S, Bessot N, Sesboüé B, Bulla J, Davenne D. Circadian Characteristics of Older Adults and Aerobic Capacity. J Gerontol A Biol Sci Med Sci. 2016;71 (6):817-822.
DOI: 10.1093/gerona/glv195
Durrington HJ, Farrow SN, Loudon AS, Ray DW. The circadian clock and asthma. Thorax. 2014; 69 (1):90-2.
DOI: 10.1136/thoraxjnl-2013-203482
Dzogang F, Lightman S, Cristianini N. Diurnal variations of psychometric indicators in Twitter content. PLoS One. 2018;13 (6): e0197002. Published 2018 Jun 20.
DOI: 10.1371/journal.pone.0197002
El Allali K, Farsi H, Piro M, et al. Smartphone and a freely available application as a new tool to record locomotor activity rhythm in large mammals and humans. Chronobiol Int. 2019; 15:1-11. [Epub ahead of print]
DOI: 10.1080/07420528.2019.1609980
Eckel-Mahan K, Sassone-Corsi P. Metabolism and the circadian clock converge. Physiol Rev. 2013;93 (1):107-135.
DOI: 10.1152/physrev.00016.2012
Edgar R. S., Green E. W., Zhao Y. et al. Peroxiredoxins are conserved markers of circadian rhythms. Nature. 2012; 485: 459-464.
Eriguchi M, Levi F, Hisa T, Yanagie H, Nonaka Y, Takeda Y. Chronotherapy for cancer. Biomed Pharmacother. 2003 Oct;57 Suppl 1:92s-95s.
Escobar C., Salgado-Delgado R., Gonzalez-Guerra E., et al. Circadian disruption leads to loss of homeostasis and disease. Sleep Disord. 2011; 2011:964510.
DOI: 10.1155/2011/964510
Feeney KA, Hansen LL, Putker M, et al. Daily magnesium fluxes regulate cellular timekeeping and energy balance. Nature. 2016; 532 (7599):375-379.
Gery S, Koeffler HP. Circadian rhythms and cancer. Cell Cycle. 2010;9 (6):1097-1103.
DOI: 10.4161/cc.9.6.11046
Goh GH, Maloney SK, Mark PJ, Blache D. Episodic Ultradian Events-Ultradian Rhythms. Biology (Basel). 2019;8 (1):15. Published 2019 Mar 14.
DOI: 10.3390/biology8010015
Golombek DA, Rosenstein RE. Physiology of circadian entrainment. Physiol Rev. 2010; 90 (3):1063-102.
Gonze D, Bernard S, Waltermann C, Kramer A, Herzel H. Spontaneous synchronization of coupled circadian oscillators. Biophys J. 2005;89 (1):120-129.
DOI: 10.1529/biophysj.104.058388
Gouda M, Matsukawa M, Iijima H. Associations between eating habits and glycemic control and obesity in Japanese workers with type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2018; 11:647-658. 10.2147/DMSO.S176749. eCollection 2018.
DOI: 10.2147/DMSO.S176749.eCollection2018
Grant AD, Wilsterman K, Smarr BL, Kriegsfeld LJ. Evidence for a Coupled Oscillator Model of Endocrine Ultradian Rhythms. J Biol Rhythms. 2018;33 (5):475-496.
DOI: 10.1177/0748730418791423
Gubin G. D. Changes in the Metabolite Content of Tissue Preserved by V. P. Filatov's Method. Bulletin of Experimental Biology and Medicine. 1959. Т. 46. № 4. С. 1246-1250.
Gubin G. D., Pospelova N. A., Vlasova V. S. Diurnal Rhythm of RNA and glycogen in fasting animals. Bulletin of Experimental Biology and Medicine. 1968. Т. 65. № 5. С. 555-557.
Gubin G. D. Vital Fixation of Dye by Tissues and Diurnal Physiological Rhythm. Bulletin of Experimental Biology and Medicine. 1968. Т. 66. № 2. С. 914-916.
Gubin D., Gubin G., Cornélissen G., et al. The human blood pressure chronome: a biological gauge of aging. In Vivo. 1997; 11 (6): 485-494.
Gubin D. G., Cornelissen G., Halberg F. et al. Half-weekly and weekly blood pressure patterns in late human ontogeny. Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae. 1997; 70: 207-216.
Gubin D., Cornelissen G., Weinert D. et al. Circadian disruption and Vascular Variability Disorders (VVD) - mechanisms linking aging, disease state and Arctic shift-work: applications for chronotherapy. World Heart Journal. 2013; 5 (4): 285-306.
Gubin D. G., Gubin G. D., Gapon L. I., Weinert D. Daily Melatonin Administration Attenuates Age-Dependent Disturbances of Cardiovascular Rhythms. Curr. Aging Sci. 2016; 9 (1): 5-13.
Gubin DG, Weinert D, Bolotnova TV. Age-Dependent Changes of the Temporal Order - Causes and Treatment. Curr Aging Sci. 2016;9 (1):14-25.
Gubin D. G., Weinert D., Rybina S. V., et al. Activity, Sleep and Ambient Light Have a Different Impact on Circadian Blood Pressure, Heart Rate and Body Temperature Rhythms. Chronobiology Int. 2017; 34 (5): 632-649.
DOI: 10.1080/07420528.2017.1288632
Gubin D. G., Nelaeva A. A., Uzhakova A. E., et al. Disrupted circadian rhythms of body temperature, heart rate and fasting blood glucose in prediabetes and type 2 diabetes mellitus. Chronobiol Int. 2017; 34 (8):1136-1148.
DOI: 10.1080/07420528.2017.1347670
Gubin D. G., Malishevskaya T. N., Astakhov Y. S., et al. Progressive retinal ganglion cell loss in primary open-angle glaucoma is associated with temperature circadian rhythm phase delay and compromised sleep. Chronobiol Int. 2019; 36 (4):564-577.
DOI: 10.1080/07420528.2019.1566741
Gubin D. G., Weinert D., Solovieva S. V., et al. Melatonin attenuates effects of light-at-night on systolic blood pressure and body temperature but does not affect diastolic blood pressure and heart rate circadian rhythms. Biological Rhythm Research, 2019. Online.
DOI: 10.1080/09291016.2018.1564586
Halberg F, Visscher MB. Regular diurnal physiological variation in eosinophil levels in five stocks of mice. Proc Soc exp Biol (N.Y.) 1950; 75:846-847.
DOI: 10.3181/00379727-75-18365
Halberg F. [Physiologic 24-hour periodicity; general and procedural considerations with reference to the adrenal cycle]. Int Z Vitaminforsch Beih 1959; 10:225-96.
Halberg F, Cornélissen G, Otsuka K, et al. Cross-spectrally coherent ~10.5- and 21-year biological and physical cycles, magnetic storms and myocardial infarctions. Neuroendocrinol Lett. 2000; 21:233-258.
Halberg F, Cornélissen G, Katinas G, et al. Transdisciplinary unifying implications of circadian findings in the 1950s. J Circadian Rhythms. 2003;1 (1):2. Published 2003 Oct 29.
DOI: 10.1186/1740-3391-1-2
Halberg F, Powell D, Otsuka K, et al. Diagnosing vascular variability anomalies, not only MESOR-hypertension. Am J Physiol Heart Circ Physiol. 2013;305 (3): H279-H294.
DOI: 10.1152/ajpheart.00212.2013
Harding EC, Franks NP, Wisden W. The Temperature Dependence of Sleep. Front Neurosci. 2019; 13:336. Published 2019 Apr 24.
DOI: 10.3389/fnins.2019.00336
Hieke AC, Hubert SM, Athrey G. Circadian disruption and divergent microbiota acquisition under extended photoperiod regimens in chicken. PeerJ. 2019;7: e6592. Published 2019 Mar 14.
DOI: 10.7717/peerj.6592
Hermida RC, Ayala DE, Mojón A, Fernández JR. Blunted sleep-time relative blood pressure decline increases cardiovascular risk independent of blood pressure level - the "normotensive non-dipper" paradox. Chronobiol Int. 2013; 30 (1-2):87-98. Epub 2012 Oct 5.
DOI: 10.3109/07420528.2012.701127
Hermida R. C., Ayala D. E., Smolensky M. H., et al. Sleep-time blood pressure: Unique sensitive prognostic marker of vascular risk and therapeutic target for prevention. Sleep Med Rev. 2017. 33: 17-27.
DOI: 10.1016/j.smrv.2016.04.001
Hermida RC, Ayala DE, Fernández JR, Mojón A, Smolensky MH. Hypertension: New perspective on its definition and clinical management by bedtime therapy substantially reduces cardiovascular disease risk. Eur J Clin Invest. 2018; 48 (5): e12909. Epub 2018 Feb 25.
DOI: 10.1111/eci.12909
Honma K, Honma S, Kohsaka M, Fukuda N. Seasonal variation in the human circadian rhythm: dissociation between sleep and temperature rhythm. Am J Physiol. 1992; 262 (5 Pt 2): R885-91.
Hrushesky W. J. Circadian timing of cancer chemotherapy. Science. 1985: 228, 73-75.
Hughes ME, Abruzzi KC, Allada R, et al. Guidelines for Genome-Scale Analysis of Biological Rhythms. J Biol Rhythms. 2017;32 (5):380-393.
DOI: 10.1177/0748730417728663
Hughey JJ, Hastie T, Butte AJ. ZeitZeiger: Supervised learning for high-dimensional data from an oscillatory system. Nucleic Acids Res. 2016;44: e80.
Hughey JJ. Machine learning identifies a compact gene set for monitoring the circadian clock in human blood. Genome Med. 2017; 9:19.
Husse J, Eichele G, Oster H. Synchronization of the mammalian circadian timing system: Light can control peripheral clocks independently of the SCN clock: Alternate routes of entrainment optimize the alignment of the body's circadian clock network with external time. Bioessays. 2015; 37 (10):1119-1128.
Jakubowicz D, Wainstein J, Landau Z, et al. Influences of Breakfast on Clock Gene Expression and Postprandial Glycemia in Healthy Individuals and Individuals With Diabetes: A Randomized Clinical Trial. Diabetes Care. 2017 Nov;40 (11):1573-1579. Epub 2017 Aug 22.
DOI: 10.2337/dc16-2753
Jansen SW, Akintola AA, Roelfsema F, et al. Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. Sci Rep. 2015; 5:11525. Published 2015 Jun 19.
DOI: 10.1038/srep11525
Jehan S, Masters-Isarilov A, Salifu I, et al. Sleep Disorders in Postmenopausal Women. J Sleep Disord Ther. 2015;4 (5):1000212.
DOI: 10.4172/2167-0277.1000212
Johnson F, Mavrogianni A, Ucci M, Vidal-Puig A, Wardle J. Could increased time spent in a thermal comfort zone contribute to population increases in obesity? Obes Rev. 2011 Jul;12 (7):543-51.
DOI: 10.1111/j.1467-789X.2010.00851.x
Johnston JD, Ordovás JM, Scheer FA, Turek FW. Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans. Adv Nutr. 2016;7 (2):399-406. Published 2016 Mar 9.
DOI: 10.3945/an.115.010777
Juda M., Vetter C., Roenneberg T. Chronotype modulates sleep duration, sleep quality, and social jet lag in shift-workers. J. Biol. Rhythms. 2013; 28 (2):141-51.
Kaczmarek JL, Musaad SM, Holscher HD. Time of day and eating behaviors are associated with the composition and function of the human gastrointestinal microbiota. Am J Clin Nutr. 2017 Nov;106 (5):1220-1231. Epub 2017 Sep 27.
DOI: 10.3945/ajcn.117.156380
Kalafatakis K, Russell GM, Harmer CJ, et al. Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man. Proc Natl Acad Sci USA. 2018;115 (17): E4091-E4100.
DOI: 10.1073/pnas.1714239115
Kalmbach DA, Schneider LD, Cheung J, et al. Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS. Sleep. 2017; 40 (2): zsw048.
DOI: 10.1093/sleep/zsw048
Katchman BA, Zhu M, Blain Christen J, Anderson KS. Eccrine Sweat as a Biofluid for Profiling Immune Biomarkers. Proteomics Clin Appl. 2018;12 (6): e1800010.
DOI: 10.1002/prca.201800010
Kettner NM, Voicu H, Finegold MJ, et al. Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. Cancer Cell. 2016;30 (6):909-924.
DOI: 10.1016/j.ccell.2016.10.007
Klerman EB, Gershengorn HB, Duffy JF, Kronauer RE. Comparisons of the variability of three markers of the human circadian pacemaker. J Biol Rhythms. 2002; 17:181-193.
Kolbe I, Oster H. Chronodisruption, Metabolic Homeostasis, and the Regulation of Inflammation in Adipose Tissues. Yale J Biol Med. 2019;92 (2):317-325. Published 2019 Jun 27.
Laing EE, Möller-Levet CS, Poh N, et al. Blood transcriptome based biomarkers for human circadian phase. Elife. 2017;6: e20214. Published 2017 Feb 20.
DOI: 10.7554/eLife.20214
Leocadio-Miguel M.A., Louzada F. M., Duarte L. L., et al. Latitudinal cline of chronotype. Scientific Reports. 2017; 7:5437.
Levi F., Giacchetti S, Zidani R, Brezault-Bonnet C, Tigaud JM, Goldwasser F, Misset JL. Chronotherapy of colorectal cancer metastases. Hepatogastroenterology. 2001. 48, 320-322
Lévi F. Circadian chronotherapy for human cancers. Lancet Oncol. 2001; 2 (5):307-15.
Lévi F, Okyar A, Dulong S, Innominato PF, Clairambault J. Circadian timing in cancer treatments. Annu Rev Pharmacol Toxicol. 2010; 50:377-421.
DOI: 10.1146/annurev.pharmtox.48.113006.094626
Lewy AJ, Cutler NL, Sack RL. The endogenous melatonin profile as a marker of circadian phase position. J Biol Rhythms. 1999; 14:227-236
Li HX. The role of circadian clock genes in tumors. Onco Targets Ther. 2019; 12:3645-3660. Published 2019 May 13.
DOI: 10.2147/OTT.S203144
Li Y, Hao Y, Fan F, Zhang B. The Role of Microbiome in Insomnia, Circadian Disturbance and Depression. Front Psychiatry. 2018; 9:669. Published 2018 Dec 5.
DOI: 10.3389/fpsyt.2018.00669
Libert S, Bonkowski MS, Pointer K, Pletcher SD, Guarente L. Deviation of innate circadian period from 24 h reduces longevity in mice. Aging Cell. 2012;11 (5):794-800.
DOI: 10.1111/j.1474-9726.2012.00846.x
Longo VD, Panda S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016;23 (6):1048-1059.
DOI: 10.1016/j.cmet.2016.06.001
Masri S, Sassone-Corsi P. The emerging link between cancer, metabolism, and circadian rhythms. Nat Med. 2018;24 (12):1795-1803.
DOI: 10.1038/s41591-018-0271-8
Mazzoccoli G., Pazienza V., Vinciguerra M. Clock genes and clock-controlled genes in the regulation of metabolic rhythms. Chronobiol Int. 2012; 29 (3):227-51.
DOI: 10.3109/07420528.2012.658127
Millius A, Ueda H. R. Systems Biology-Derived Discoveries of Intrinsic Clocks. Frontiers in Neurology. 2017; 8:25.
Minors D., Waterhouse J., Wirz-Justice A. A human phase-response curve to light. Neurosci Lett. 1991; 133:36-40.
Möller-Levet CS, Archer SN, Bucca G, et al. Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci U S A. 2013;110 (12): E1132-E1141.
DOI: 10.1073/pnas.1217154110
Munje RD, Muthukumar S, Jagannath B, Prasad S. A new paradigm in sweat based wearable diagnostics biosensors using Room Temperature Ionic Liquids (RTILs). Sci Rep. 2017;7 (1):1950. Published 2017 May 16.
DOI: 10.1038/s41598-017-02133-0
Mure LS, Le HD, Benegiamo G, et al. Diurnal transcriptome atlas of a primate across major neural and peripheral tissues. Science. 2018; 359 (6381): eaao0318.
DOI: 10.1126/science.aao0318
Nelson W., Halberg F. Schedule-shifts, circadian rhythms and lifespan of freely-feeding and meal-fed mice. Physiol. Behav. 1986; 38:781-788. 10.1016/0031-9384 (86) 90043-0.
DOI: 10.1016/0031-9384(86)90043-0
Oda GA, Friesen WO. Modeling two-oscillator circadian systems entrained by two environmental cycles. PLoS One. 2018;6 (8): e23895.
DOI: 10.1371/journal.pone.0023895
Panda S. The arrival of circadian medicine. Nat Rev Endocrinol. 2019 Feb;15 (2):67-69.
DOI: 10.1038/s41574-018-0142-x
Park YM, White AJ, Jackson CL, Weinberg CR, Sandler DP. Association of Exposure to Artificial Light at Night While Sleeping With Risk of Obesity in Women. JAMA Intern Med. 2019 Jun 10. [Epub ahead of print]
DOI: 10.1001/jamainternmed.2019.0571
Parkar SG, Kalsbeek A, Cheeseman JF. Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health. Microorganisms. 2019;7 (2):41. Published 2019 Jan 31.
DOI: 10.3390/microorganisms7020041
Parry BL, Meliska CJ, Sorenson DL, et al. Increased melatonin and delayed offset in menopausal depression: role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index. J Clin Endocrinol Metab. 2008;93 (1):54-60.
DOI: 10.1210/jc.2006-2853
Partch C., Green C., Takahashi J. Molecular Architecture of the Mammalian Circadian Clock. Trends in cell biology. 2014; 24 (2):90-99.
Patel JC, Khurana P, Sharma YK, Kumar B, Ragumani S. Chronic lifestyle diseases display seasonal sensitive comorbid trend in human population evidence from Google Trends. PLoS One. 2018;13 (12): e0207359. Published 2018 Dec 12.
DOI: 10.1371/journal.pone.0207359
Plikus MV, Andersen B. Skin as a window to body-clock time. Proc Natl Acad Sci USA. 2018;115 (48):12095-12097.
DOI: 10.1073/pnas.1817419115
Pittendrigh CS, Bruce VG. Daily rhythms as coupled oscillator systems and their relation to thermoperiodism and photoperiodism. In: Withrow RB, editor. In Photoperiodism and related phenomena in plants and animals. Washington, DC: Am Assoc Adv Sci; 1959. pp. 475-505
Poggiogalle E, Jamshed H, Peterson CM. Circadian regulation of glucose, lipid, and energy metabolism in humans. metabolism. 2018; 84:11-27.
DOI: 10.1016/j.metabol.2017.11.017
Potter GD, Skene DJ, Arendt J, et al. Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures. Endocr Rev. 2016;37 (6):584-608.
DOI: 10.1210/er.2016-1083
Provencio I., Warthen D. M. Melanopsin, the photopigment of intrinsically photosensitive retinal ganglion cells. Wiley Interdiscip Rev Membr Transp Signal. 2012; 1 (2):228-23.
Purnell BS, Thijs RD, Buchanan GF. Dead in the Night: Sleep-Wake and Time-Of-Day Influences on Sudden Unexpected Death in Epilepsy. Front Neurol. 2018; 9:1079. Published 2018 Dec 11.
DOI: 10.3389/fneur.2018.01079
Putilov A. A., Donskaya O. G., Verevkin E. G. How many diurnal types are there? A search for two further "bird species". Personality and Individual Differences. 2015. 72: 12-17.
Putilov A. A., Dorokhov V. B., Puchkova A. N., Arsenyev G. N., Sveshnkiov D. S. Genetic-based signatures of the latitudinal differences in chronotype. Biological Rhythm Research, 2018.
DOI: 10.1080/09291016.2018.1465249
Putilov AA. Owls, larks, swifts, woodcocks and they are not alone: A historical review of methodology for multidimensional self-assessment of individual differences in sleep-wake pattern. Chronobiol Int. 2017;34 (3):426-437. Epub 2017 Jan 27.
DOI: 10.1080/07420528.2017.1278704
Putker M, Crosby P, Feeney KA, et al. Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations. Antioxid Redox Signal. 2018; 28 (7):507-520.
DOI: 10.1089/ars.2016.6911
Reinberg A., Smolensky MH., Touitou Y. The full moon as a synchronizer of circa-monthly biological rhythms: Chronobiologic perspectives based on multidisciplinary naturalistic research. Chronobiol Int. 2016; 33 (5):465-79.
DOI: 10.3109/07420528.2016.1157083
Reinberg AE, Dejardin L, Smolensky MH, Touitou Y. Seven-day human biological rhythms: An expedition in search of their origin, synchronization, functional advantage, adaptive value and clinical relevance. Chronobiol Int. 2017; 34 (2):162-191.
DOI: 10.1080/07420528.2016.1236807
Reppert S. M., Weaver D. R. Coordination of circadian timing in mammals. Nature. 2002. 418, 935-941.
DOI: 10.1038/nature00965
Roche VP, Mohamad-Djafari A, Innominato PF, et al. Thoracic surface temperature rhythms as circadian biomarkers for cancer chronotherapy. Chronobiol Int. 2014; 31 (3):409-420.
DOI: 10.3109/07420528.2013.864301
Roenneberg T, Wirz-Justice A, Merrow M. Life between clocks: daily temporal patterns of human chronotypes. J Biol Rhythms. 2003; 18:80-90.
Roenneberg T., Kuehnle T., Juda M. et al. Epidemiology of the human circadian clock. Sleep Med Rev. 2007; 11 (6):429-38.
Ruben MD, Wu G, Smith DF, et al. A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine. Sci Transl Med. 2018; 10 (458). pii: eaat8806.
DOI: 10.1126/scitranslmed.aat8806
Sandler O., Mizrahi S. P., Weiss N., et al. Lineage correlations of single cell division time as a probe of cell-cycle dynamics. Nature. 2015 Mar 26;519 (7544):468-71. Epub 2015 Mar 11.
DOI: 10.1038/nature14318
Scheer FA, Shea SA. Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle. Blood. 2014;123 (4):590-593.
DOI: 10.1182/blood-2013-07-517060
Schmal C, Herzog ED, Herzel H. Measuring Relative Coupling Strength in Circadian Systems. J Biol Rhythms. 2018;33 (1):84-98.
DOI: 10.1177/0748730417740467
Schwartz MD, Congdon S, de la Iglesia HO. Phase misalignment between suprachiasmatic neuronal oscillators impairs photic behavioral phase shifts but not photic induction of gene expression. J Neurosci. 2010; 30 (39):13150-6.
DOI: 10.1523/JNEUROSCI.1853-10.2010
Skene DJ, Skornyakov E, Chowdhury NR, et al. Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism. Proc Natl Acad Sci USA. 2018;115 (30):7825-7830.
DOI: 10.1073/pnas.1801183115
Smolensky MH, Reinberg AE, Fischer FM. Working Time Society consensus statements: Circadian time structure impacts vulnerability to xenobiotics-relevance to industrial toxicology and nonstandard work schedules. Ind Health. 2019;57 (2):158-174.
DOI: 10.2486/indhealth.SW-2
Squire T, Buchanan G, Rangiah D, et al. Does chronomodulated radiotherapy improve pathological response in locally advanced rectal cancer? Chronobiol Int. 2017;34 (4):492-503. Epub 2017 Mar 29.
DOI: 10.1080/07420528.2017.1301462
Strogatz SH, Stewart I. Coupled oscillators and biological synchronization. Sci Am. 1993 Dec;269 (6):102-9.
Sulli G, Rommel A, Wang X, et al. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. 2018;553 (7688):351-355.
DOI: 10.1038/nature25170
Sutton EF, Beyl R, Early KS, et al. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab. 2018; 27 (6):1212-1221.e3.
DOI: 10.1016/j.cmet.2018.04.010
Takahashi J. S. Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet. 2017; 18 (3):164-179.
Takahashi M, Haraguchi A, Tahara Y, et al. Positive association between physical activity and PER3 expression in older adults. Sci Rep. 2017; 7: 39771.
DOI: 10.1038/srep39771
Tokuda IT, Ono D, Honma S, Honma KI, Herzel H. Coherency of circadian rhythms in the SCN is governed by the interplay of two coupling factors. PLoS Comput Biol. 2018;14 (12): e1006607. Published 2018 Dec 10.
DOI: 10.1371/journal.pcbi.1006607
Touitou Y., Reinberg A., Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption. Life Sci. 2017. 15; 173:94-106.
Troutt JS, Rudling M, Persson L, et al. Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration. Clin Chem. 2012 Aug;58 (8):1225-32. Epub 2012 Jun 7.
DOI: 10.1373/clinchem.2012.186866
Turco M, Biscontin A, Corrias M, et al. Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3. Sci Rep. 2017;7 (1):6967. Published 2017 Jul 31.
DOI: 10.1038/s41598-017-06769-w
Van Cauter E, Spiegel K: Circadian and sleep control of hormones. In Turek FW, Zee PC (eds): Regulation of Sleep and Circadian Rhythms. New York: Marcel Dekker, 1999, p. 399
van den Berg R, Noordam R, Kooijman S, et al. Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals. Aging Cell. 2017;16 (2):237-243.
DOI: 10.1111/acel.12547
van der Veen DR, Gerkema MP. Unmasking ultradian rhythms in gene expression. FASEB J. 2017;31 (2):743-750.
DOI: 10.1096/fj.201600872R
van der Vorst EPC, Peters LJF, Müller M, et al. G-Protein Coupled Receptor Targeting on Myeloid Cells in Atherosclerosis. Front Pharmacol. 2019; 10:531. Published 2019 May 22.
DOI: 10.3389/fphar.2019.00531
Vargas I, Vgontzas AN, Abelson JL, et al. Altered ultradian cortisol rhythmicity as a potential neurobiologic substrate for chronic insomnia. Sleep Med Rev. 2018; 41:234-243.
DOI: 10.1016/j.smrv.2018.03.003
Vieira Musse GN, Moreira T, Ayumi Kimura M, et al. Skipping breakfast concomitant with late-night dinner eating is associated with worse outcomes following ST-segment elevation myocardial infarction. Eur J Prev Cardiol. 2019 Apr 17:2047487319839546. [Epub ahead of print]
DOI: 10.1177/2047487319839546
Vlachou D., Bjarnason G. A., Giacchetti S., Lévi F., Rand D. A. TimeTeller: a New Tool for Precision Circadian Medicine and Cancer Prognosis. bioRxiv. 622050;
DOI: 10.1101/622050
Voigt RM, Forsyth CB, Green SJ, et al. Circadian disorganization alters intestinal microbiota. PLoS One. 2014;9 (5): e97500. Published 2014 May 21.
DOI: 10.1371/journal.pone.0097500
Walker JJ, Terry JR, Lightman SL. Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis. Proc Biol Sci. 2010;277 (1688):1627-1633.
DOI: 10.1098/rspb.2009.2148
Walters JF, Hampton SM, Ferns GA, Skene DJ. Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditions. Chronobiology international. 2005; 22:859-872.
Ward EM, Germolec D, Kogevinas M, et al. Carcinogenicity of night shift work. Lancet Oncol. 2019 Jul 4. pii: S1470-2045 (19) 30455-3. 10.1016/S1470-2045 (19) 30455-3.
DOI: 10.1016/S1470-2045(19)30455-3
Weljie AM, Meerlo P, Goel N, et al. Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. Proc Natl Acad Sci USA. 2015;112 (8):2569-2574.
Weinert D., Gubin D. The Circadian Body Temperature Rhythm - Origin and Implications for Health and Wellbeing. Tyumen Medical Journal. 2018. 20 (2):6-14. (Weinert D., Gubin D. G. The Circadian Body Temperature Rhythm - Origin and Implications for Health and Wellbeing. Тюменский медицинский журнал. 2018. Т. 20. № 2. С. 6-14.
Winczyk K, Pawlikowski M. Time of day-dependent effects of thyroliberin and thyrotropin on thymocyte proliferation in rats. Neuroimmunomodulation.2000. 7: 89-91.
DOI: 10.1159/000026425
Winter C., Silvestre-Roig C., Ortega-Gomez A., et al. Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis. Cell Metab. 2018 Jul 3;28 (1):175-182.e5.
DOI: 10.1016/j.cmet.2018.05.002
Wittenbrink N, Ananthasubramaniam B, Münch M, et al. High-accuracy determination of internal circadian time from a single blood sample. J Clin Invest. 2018;128 (9):3826-3839.
DOI: 10.1172/JCI120874
Woelders T., Beersma D., Gordijn M., et al. Daily Light Exposure Patterns Reveal Phase and Period of the Human Circadian Clock. J. Biol. Rhythms. 2017; 32 (3):274-286.
Wong PM, Hasler BP, Kamarck TW, Muldoon MF, Manuck SB. Social jetlag, chronotype, and cardiometabolic risk. J Clin Endocrinol Metab. 2015;100 (12):4612-4620.
Wu L, Reddy AB. Rethinking the clockwork: redox cycles and non-transcriptional control of circadian rhythms. Biochem Soc Trans. 2014; 42 (1):1-10.
DOI: 10.1042/BST20130169
Wu YE, Enoki R, Oda Y, et al. Ultradian calcium rhythms in the paraventricular nucleus and subparaventricular zone in the hypothalamus. Proc Natl Acad Sci USA. 2018;115 (40): E9469-E9478.
DOI: 10.1073/pnas.1804300115
Wu G, Ruben MD, Schmidt RE, et al. Population-level rhythms in human skin with implications for circadian medicine. Proc Natl Acad Sci USA. 2018;115 (48):12313-12318.
DOI: 10.1073/pnas.1809442115
Wyse CA, Selman C, Page MM, Coogan AN, Hazlerigg DG. Circadian desynchrony and metabolic dysfunction; did light pollution make us fat? Med Hypotheses. 2011 Dec;77 (6):1139-44.
DOI: 10.1016/j.mehy.2011.09.023
Zavala E, Wedgwood KCA, Voliotis M, et al. Mathematical Modelling of Endocrine Systems. Trends Endocrinol Metab. 2019;30 (4):244-257.
DOI: 10.1016/j.tem.2019.01.008
Zhao J, Warman GR, Cheeseman JF. Clock gene expression and locomotor activity predict death in the last days of life in Drosophila melanogaster. Sci Rep. 2018;8 (1):11923. Published 2018 Aug 9.
DOI: 10.1038/s41598-018-30323-x
Zhu B, Zhang Q, Pan Y, et al. A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms. Cell Metab. 2017;25 (6):1305-1319.e9.
DOI: 10.1016/j.cmet.2017.05.004
Zhu S, Ge J, Liu Z, et al. Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats. Front Neurol. 2017 Mar 15; 8:101. 10.3389/fneur.2017.00101. eCollection 2017.
DOI: 10.3389/fneur.2017.00101.eCollection2017
Zylka MJ, Shearman LP, Weaver DR, Reppert SM. Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron. 1998; 20 (6):1103-10.
Агаджанян Н. А., Губин Д. Г. Десинхроноз: механизмы развития от молекулярно-генетического до системного уровня. Успехи физиол. наук. 2004; 35 (2): 57-72.
Ветошкин А. С. Эффективность хронотерапии артериальной гипертонии с учетом клинико-патогенентических особенностей хроноструктуры артериального давления в условиях вахтового режима труда в Заполярье. Дисс… д. м. н., Томск, 2014, 316 с.
Ветошкин А. С., Шуркевич Н. П., Гапон Л. И. и др. Возможности хронотерапии в восстановлении суточного ритма артериального давления у больных артериальной гипертонией в условиях вахты за Полярным кругом (Ямбург). Справочник врача общей практики. 2014; (3): 47-56.
Губин Г. Д., Чесноков А. А. Биоритм как диагностический тест нормы и патологии. Лабораторное дело. 1976. № 7. С. 432.
Губин Г. Д., Герловин Е. Ш. Суточные ритмы биологических процессов и их адаптивное значение в онто- и филогенезе позвоночных. Новосибирск: Наука, 1980. 276 с.
Губин Г. Д., Вайнерт Д. Биоритмы и возраст. Успехи физиол. наук. 1991. Т. 22. С. 77-96.
Губин Г. Д., Губин Д. Г. Классификация десинхронозов по причинному фактору и механизмам развития. Фундаментальные исследования. 2004; 1:50.
Губин Д. Г., Губин Г. Д., Гапон Л. И. Преимущества использования хронобиологических нормативов при анализе данных амбулаторного мониторинга артериального давления. Вестник аритмологии. 2000. 16: 84-94.
Губин Д. Г. Молекулярные механизмы циркадианных ритмов и принципы развития десинхроноза. Успехи физиологических наук. 2013. Т. 44, № 4. С. 65-87.
Губин Д. Г. Околонедельные (циркасептанные) ритмы в физиологии (обзор). Успехи современного естествознания. - 2015. - № 1-8. - С. 1268-1272
Губин Д. Г., Ветошкин А. С., Болотнова Т. В. и др. Взаимосвязь суточного профиля, вариабельности и структуры циркадианных ритмов артериального давления и частоты сердечных сокращений с хронотипом у вахтовиков Арктики. Медицинская наука и образование Урала. 2015. Т. 16. № 2-1 (82). С. 108-113.
Губин Д. Г. Околонедельные (циркасептанные) ритмы в физиологии (обзор). Успехи современного естествознания. 2015. № 1-8. С. 1268-1272.
Губин Д. Г., Вайнерт Д. Динамика временной организации в процессе старения: I. Центральные и периферические механизмы. Успехи геронтологии. 2015; Т. 28 N 2. С.257-268.
Губин Д. Г., Вайнерт Д. Динамика временной организации в процессе старения: 2. Системные механизмы и способы коррекции возрастного десинхроноза. Успехи геронтологии 2015; Т. 28 N 3. С.423-434.
Губин Д. Г., Вайнерт Д., Соловьева С. В. и др. Эндогенный суточный ритм артериального давления в норме. Как он выглядит и его отличия от результатов амбулаторного мониторинга. Тюменский медицинский журнал. 2018. Т. 20. № 1. С. 3-6.
Губин Д. Г., Вайнерт Д., Соловьева С. В., Дуров А. М. Роль активности, сна и внешней освещенности в суточной динамике артериального давления // Медицинский алфавит. 2018. № 3, том № 1. Артериальная гипертензия. С. 20-23.
Губин Д. Г., Малишевская Т. В., Вайнерт Д., и др. Особенности циркадианного ритма внутриглазного давления при стабильной и прогрессирующей первичной открытоугольной форме глаукомы. Тюменский медицинский журнал. 2018. Т. 20, № 3: 3-9.
Шипицина Н.В, Шуркевич Н. П., Ветошкин А. С. и др. Эффективность годовой хронотерапии ингибитором АПФ (лизиноприл) у больных артериальной гипертонией условиях заполярной вахты. Уральский медицинский журнал. 2014; 3: С. 89-94.
Шуркевич Н. П., Ветошкин А. С., Пошинов Ф. А. и др. Влияние хронотерапии на клиническое течение и образ жизни больных артериальной гипертонией в условиях заполярной вахты Уральский медицинский журнал. 2013; 106 (3): 41-48.
Шуркевич Н. П., Шипицына Н. В., Ветошкин А. С. и др. Преимущества хронотерапии антагонистом кальция и бета-адреноблокатором у больных артериальной гипертонией в условиях вахтового труда в заполярье. Уральский медицинский журнал. 2015; 1 (124): 57-63.
Шуркевич Н. П., Ветошкин А. С., Губин Д. Г. и др. Преимущества персонализированного подхода к хронотерапии артериальной гипертензии у вахтовиков Ямала. Артериальная гипертензия. 2016; (22) 1: 6-14.

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