Identification of cyanide adduct with human serum albumin using mass-spectrometry
Автор: Dubrovskiy Ya. A., Murashko E.A., Kombarova M. Yu., Podolskaya E.P., Babakov V.N., Krasnov N.V., Radilov A.S.
Журнал: Научное приборостроение @nauchnoe-priborostroenie
Рубрика: Масс-спектрометрия
Статья в выпуске: 1 т.23, 2013 года.
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MALDI mass spectrometry was used to identify cyanide adducts with human serum albumin. Peptide with M H + 999.44 Da was detected in the tryptic digestion of human serum albumin, incubated with cyanide (sodium and potassium salts). As a result SCN adduct at Cys-34 are formed. The sequence Cys-Pro-Phe-Glu-Asp-His-Val-Lys was confirmed by HPLC-MS-MS analysis on ion trap.
Maldi, maldi-tof, ion trap, serum albumin, cyanide
Короткий адрес: https://sciup.org/14264841
IDR: 14264841
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