Identification of biomarkers of schizophrenia using mass spectrometry methods (literature review)

Objective: to analyze the results of modern domestic and foreign studies of biological markers of schizophrenia using mass spectrometry methods, highlight the main promising areas of research in the field of metabolomics and proteomics in schizophrenia, discuss the principles of operation and modern capabilities of various modifications of mass spectrometers in the analysis of proteomic and metabolomic composition of biological fluids of patients with schizophrenia. As a result of the analysis of literature data with a generalization of the currently available results of original studies, systematic reviews and meta-analyses, information is presented on the main groups of biomarkers and the leading mechanisms of pathogenesis, which are currently most actively studied in schizophrenia by mass spectrometry, as well as on the limitations of metabolomics in the study of this disease.