Immunopharmacological aspects of the chorionic gonadotropin application

The review presents data on the role of chorionic gonadotropin (CG) in the regulation of the immune system. The effects of CG on the functional activity of dendritic cells, the main subsets of helper T cells (Th1, Th2, Th17, Treg), memory T cells, as well as B cells were analyzed. The immunopharmacological potential of the hormone is closely related to its ability to modulate the functional activity of the listed immune cell subsets. In addition to the targeted effects of CG at the level of reproductive tissues, the review discusses the prospects for the possible use of the hormone in the treatment of autoimmune diseases and post-transplant complications. The effects of CG at the immune system are important also in connection with its use in preparation for in vitro fertilization (IVF). Thus, due to the pleiotropic effect of CG on the body, and the presence of non-target effects, the spectrum of its application has the potential to expand.