Immunological criteria of prediction of course and therapy of mental disorders

The investigations of features of psychoneuroimmunomodula-tion in men-tal disorders (schizophrenia, neurotic, stress-related disorders) and mental adaptation/disadaptation within continuum “health - ten-sion of mental adaptation - non-pathological disadaptation” were carried out. Pre-laboratory diagnostics of clinical syndromes of the secondary immune deficiency (infectious, allergic, autoimmune) were fulfilled, phenotypes of immunocompetent cells (CD2+, CD3+, CD4+, CD8+, CD16+, HLADR+, CD72+, CD95+); concentration of serum immunoglobulins M, G, A; level of circulating immune com-plexes; phagocytic activity of leukocytes were identified. In addition, psychological examination with evaluation of the level of mental adaptation; state and trait anxiety; mechanisms of psychological defense was conducted in mental adaptation/disadaptation. During analysis of clinical-immunological patterns the complexes of immunological parameters were revealed that may be considered as criteria for prediction of unfavorable lingering course of neurotic disorders. Efficiency of conducted antipsychotic therapy for schizophrenia patients as well as complex of the immunopsychological criteria of risk of transformation of non-pathological mental disa-daptation into nosological form of borderline pathology. The proposed predictive criteria are protected by patents of the Russian Federation.