Иммунорегуляторные функции ингибиторов PD-1/PD-L1 и развитие к ним резистентности

Автор: Саяпина Мария С.

Журнал: Злокачественные опухоли @malignanttumors

Статья в выпуске: 2 (23), 2017 года.

Бесплатный доступ

Данный обзор представляет современное понимание об ингибиторах PD-1/PD-L1. Несмотря на выраженный ответ на иммунотерапию ингибиторами чекпоинтов в ряде нозологий, в 60% случаев отмечается либо первичная, либо приобретенная резистентность. Механизмы, лежащие в основе резистентности, также освещены в данной статье.

Ингибиторы чекпоинтов, первичная/приобретенная резистентность

Короткий адрес: https://sciup.org/140223045

IDR: 140223045 | DOI: 10.18027/2224-5057-2017-2-94-99

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