Impact of silver nanoparticle concentration in alginate microcapsules on their effects on morphological changes in periodontitis

Автор: Angelina A. Savkina, Ekaterina V. Lengert, Alexey V. Ermakov, Tatyana V. Stepanova, Alexey N. Ivanov

Статья в выпуске: 4 Vol.3, 2022 года.

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Objective: to evaluate the effects of alginate microcapsules on morphological changes in periodontitis depending on silver nanoparticle concentration in them. Materials and Methods. The study was conducted on 30 rats distributed among three groups of 10 animals: the comparison group comprising animals with an experimental model of periodontitis and two experimental groups including animals with 5-week periodontitis, which were subjected to applications of the gel containing microcapsules with high (0.25 M, Group 1) and low (0.1 M, Group 2) concentrations of silver on the surface of their gums. To assess morphological changes, the mandible was sampled for subsequent examination. Results. In animals with periodontitis, changes in the supporting structure of the tooth took place, including defibration and perivascular edema in periodontal ligament of the tooth, and bone resorption via its replacement with connective tissue. The application of a gel containing microcapsules with silver nanoparticles led to a partial reduction of such disorders: particularly, it reduced bone resorption and its replacement with connective tissue. Destructive changes in periodontal tissues caused by gel with a high content of silver nanoparticles (0.25 M) were less pronounced than those caused by capsules with a low content of silver (0.1 M). Conclusion. Gels containing microcapsules with silver nanoparticles contributed to the reduction of destructive changes in the supporting structure of the tooth in periodontitis. The severity of the effects of the gel increased with an increase in the content of silver nanoparticles in alginate microcapsules.

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Periodontitis, nanoparticles, bone destruction

Короткий адрес: https://sciup.org/149146158

IDR: 149146158 | DOI: 10.15275/sarmj.2022.0401

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