Individual prognosis for stage I-II uterine leiomyosarcoma (by FIGO classification): combined biomolecular and clinic-morphological model of the 10-year survival

The retrospective study of 66 cases with uterine leiomyosarcoma and peritumorous tissue with a known prognosis was carried out. The most significant prognostic clinical and morphological criteria and biomolecular characteristics of sarcoma (microvessel density (MVD) of peritumorous tissue, tumor cell ploidy, AgNORs quantity, BrdU-label of tumor cells, degree of maturity of tumor angiogenesis, grade of malignancy by FNCLCC, nuclear translocation HSP70, level of Ki-67 expression, tumor receptor status, FIGO stage, age and tumor size) were determined by the Cox regressive multifactor analysis. Three groups of patients were formed depending on the risk level of unfavorable outcome. Group I was characterized by a favorable outcome and 83,7 % of patients in this group survived up to 10 years. In group III patients, the 5-year survival rate was 5,4 %, and none of the patients survived 10 years. Group II occupied an intermediate position. Based on the standardized approach to the analysis and difference in the 10- year survival between 3 groups at χ2=41,9, the combined model of individual survival is a predictor of the prognosis and promotes definition of the patients with favorable and unfavorable outcomes for uterine leiomyosarcoma.