Inhibitory activity of specific ligands for different binding sites of glycogen phosphorylase
Автор: Cheplyaeva N.I., Vorobiev E.S.
Журнал: Волгоградский научно-медицинский журнал @bulletin-volgmed
Рубрика: Фармакология токсикология
Статья в выпуске: 4 (48), 2015 года.
Бесплатный доступ
We compared the activity of glycogen phosphorylase inhibitors with different binding sites including a catalytic site, DAB (IC50 - 49,41 mcM), a purine binding site, caffeine (IC50 - 750 mcM) and quercetin (IC50 - 15,69 mcM), indole site, CP-316819 (lC50 - 1,24 mcM). Along with this, we found that inhibitors of two different binding sites (CP-316819 and caffeine) exert a synergistic effect both with a low and a high concentration.
Diabetes mellitus type 2, glycogen phosphorylase, glycogen phosphorylase inhibitors, catalytic site, purine site, allosteric amp site, indole site
Короткий адрес: https://sciup.org/142149144
IDR: 142149144
