The system of insulin-like growth factors in pathogenesis and prognosis of epithelial ovarian cancer

The role of the system of insulin-like growth factors (IGF) in normal folliculogenesis and in different aspects of pathogenesis of epithelial ovarian cancer is discussed. Further comprehensive assessment of IGF-system expression levels and cell motility-associated parameters in epithelial ovarian cancer are of great interest both for the advanced study of pathogenesis of these heterogeneous tumors and for the development of new molecular prognostic and predictive factors.