Интерлейкин-6 и диабетическая нефропатия: патогенетические связи, мишени для нефропротекции

Автор: Пчелин И.Ю., Байрашева В.К., Шишкин А.Н., Василькова О.Н., Худякова Н.В.

Статья в выпуске: 12, 2017 года.

Бесплатный доступ

В статье представлены данные о роли интерлейкина-6 (IL-6) в развитии диабетической нефропатии (ДН) и патогенетически связанных с ней состояний. Рассмотрены эффекты, обусловленные связыванием IL-6 с мембранным рецептором (IL-6R) и растворимым рецептором (sIL-6R). Проанализированы результаты экспериментальных и клинических исследований, направленных на изучение взаимосвязи IL-6 с ожирением, инсулинорезистентностью, нефросклерозом, кардиомиопатией и анемией. Обсуждаются различные стратегии противовоспалительной терапии и нефропротекции.

Интерлейкин-6, сахарный диабет, инсулин, инсулинорезистентность, хроническая болезнь почек, диабетическая нефропатия, тоцилизумаб

Короткий адрес: https://sciup.org/14110446

IDR: 14110446

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