Interrelation atypical infections Mycoplasma hominus siga and local immunity in chronic obstructive bronchitis in adolescents



INTERRELATION ATYPICAL INFECTIONS MYCOPLASMA HOMINUS SIGA AND LOCAL IMMUNITY IN CHRONIC OBSTRUCTIVE BRONCHITIS IN ADOLESCENTS

M.B. Kholzhigitova, N.R. Aralov

Samarkand Medical Institute, Uzbekistan Department of Hospital Therapy, Uzbekistan

Mycoplasmia hominus is an important etiologic agent of respiratory disease among young people (especially in school and pre-school age), in which the infection is often asymptomatic or mild and often goes undetected. The question of immunity to Mycoplasma hominus currently controversial and requires further study. Antimicrobial response of inflammatory mediators can not destroy Mycoplasma hominus and retain replication, but can enhance the local inflammatory proccess. The studies using PCR (Polymerase chain reaction ) and detect IgA ( as a marker of chronic infection) showed the presence of Mycoplasma hominus in most cases of chronic pulmonary infection. It is possible that Mycoplasma hominus can burden for chronic bronchitis. Detection of specific IgA in serum, the presence of specific secretory IgA indicates the possibility of the presence of the pathogen in the lungs more than 50% of patients with chronic bronchitis, decreased cellular immunity which promotes infection Mycoplasma hominus. Observations of foreign authors and our study suggest that the etiologic importance in respiratory diseases mycoplasma, is an intracellular pathogen, is much higher than previously thought. Mycoplasma etiology of bronchitis and pneumonia in children today may be from 25 to 40%, and it is the highest in the first year and after 10 years. Studied infection Mycoplasma hominus and production of secretory IgA immune system in bronchoalveolar lavage fluid of patients with chronic obstructive bronchitis in adolescence.

29 adolescents and young adults with chronic obstructive bronchitis at the age of 12 to 21years were examined. Verification of the diagnosis of chronic obstructive bronchitis conducted in allergic pulmonary department Samarkand City Medical Association, according to the international classification of WHO (X revision, ICD-10).The tests included assessment of general clinical research methods and determine the level of sIgA, which were determined by EIA (Enzyme immunoassay analisis) and PCR Mycoplasma hominus range of infections in the bronchoalveolar lavage fluid.

Evaluated: the level of secretory immunoglobulin A (sIgA) in patients with chronic obstructive bronchitis in exacerbation and spectrum of infections Mycoplasma hominus. Analysis of the parameter level of secretory sIgA in bronhlalveolyarnom lavage, the study of patients with chronic obstructive bronchitis in adolescence cause infection Mycoplasma hominus, discovered reduction sIgA. So, the content of sIgA levels in bronchoalveolar washings in patients with chronic obstructive bronchitis in adolescence was significantly reduced to 6.3±5,0 pg / ml at 15.4±3,31 pg / ml in controls (p <0.01). In the study of the spectrum of atypical pathogens in 9 cases registered invasion Mycoplasma hominus ( 31,1%), the concentration of secretory

Ig A in bronchoalveolar fluid in them was 4.3±2,14 pg/ml, while in the group of healthy controls it comes to – 15.4±3,31 pg/ml. These features sIgA production in patients with chronic obstructive bronchitis in adolescence may be the appropriate method for assessing the complex relationships between different parts of the immune response as well as a promising opportunity right choice immunotropic tsitokinoterapy. These data allows us to recommend new differentiated approach to the etiological treatment of the disease, preventing chronic recurrent inflammation in the airways of patients with chronic obstructive bronchitis.