Interstitial cystitis - pathogenesis, diagnosis and treatment strategies: an update. Part 1 - pathogenesis

Interstitial cystitis/Bladder pain syndrome (IC/BPS) is the severe pathologic condition with strong impact on quality of life. Current treatment options are not completely effective as far as IC/BPS has very complex pathogenesis, which include such factors as: 1. Urothelium’s impairment 2. Non-bacterial inflammation in the suburothelium with mast cells activation. 3. Sensitization of peripheral nervous endings. 4. Pelvic organ’s cross-talking. 5. Pelvic floor muscles overactivity. 6. Central sensitization. That’s why correct therapeutic strategies should involve all those factors.