Apisane use as immunomodulator in stimulation of postvaccinal immunity

By deprotenating and enzymatic hydrolysis of bee dead natural origin chitosan - apisane, which is used as immunomodulator of a new generation was obtained. It is established that the combined use of apisane with antiescherichial vaccine and anti-radiation polyantigene provided immunomodulating and immunostimulating effect through the activation of humoral and cellular immunity. Application of antiescherichial vaccines and radioprotective polyantigene combined with apisane for 1-15 days before the infection and exposure had radioprotective and anti-infectious effect, raising the survival of animals for 30-40% compared with the isolated application of these vaccines.