Use of halothane in experimental animals under conditions of hyperuricemia modeling

Hyperuricemia is a pathological disease in humans, mainly in Western countries, but in recent years, there has been a trend towards the incidence in Asian countries, respectively. One of the best promising models of its mechanism is its use in animal experiments, which can be extremely close to what is possible in humans. The data obtained because of the experiments made it possible to understand the deeper etiopathogenetic mechanisms for the development of purine metabolism disorders. Autopsy of experimental animals for a thorough histological and morphological examination requires the use of rapid euthanasia. However, the method must not cause unnecessary pain to the animals and must be aesthetically acceptable to the experimenters. It is important that the collection of blood samples from experimental animals be the least stressful, as stress will affect the result of the study. The use of inhalation anesthetic helps to achieve deep sleep-in rats, with further bleeding, decapitation and subsequent removal of internal organs for morphological examination.