Use of products of natural and microbial origin as radio-protective agent

The purpose of the work is the development of a radical drug based on the bacterial mass of E. coli and its study on identified animals. Two possible radiation products based on a bacterial suspension of Escherichia coli with the addition of hydroxycate and aluminum hydroxide were developed, preparation No. 1 and No. 2, respectively. The drugs are administered subcutaneously to irradiated white mice in the back at a dose of 0.2 ml for therapeutic and prophylactic purposes. The control drug was the anti-radiation therapeutic and prophylactic immunoglobulin. It was found that the use of the inactivated E. coli strain PL-6 with the addition of aluminum hydrosilicate and antiradiation treatment and prophylactic immunoglobulin as prophylactic and therapeutic agents provides 70 % survival in lethal doses of white mice. The use of aluminum hydroxide as a depositing component under these experimental conditions prevents the flexibility of 60 and 50 %, respectively.