Исследование геропротекторных и радиопротекторных эффектов берберина и трихостатина а на модели Drosophila melanogaster

Исследование геропротекторных и радиопротекторных эффектов берберина и трихостатина а на модели Drosophila melanogaster

Автор: Уляшева Н.С., Прошкина Е.Н., Шапошников М.В., Москалев А.А.

Журнал: Известия Коми научного центра УрО РАН @izvestia-komisc

Рубрика: Научные статьи

Статья в выпуске: 6 (64), 2023 года.

Бесплатный доступ

Поиск препаратов, влияющих на замедление темпов старения и стимуляцию радиоустойчивости, является актуальной задачей биологии, экологии и медицины. В данной работе изучены эффекты влияния трихостатина А и берберина на продолжительность жизни, устойчивость к прооксиданту параквату и острому гамма-излучению плодовой мушки Drosophila melanogaster. Трихостатин А оказал более выраженный геропротекторный эффект, увеличив продолжительность жизни дрозофил на 3-9 %. Однако повышение радиоустойчивости наблюдали только после применения берберина у самцов. Их медианная выживаемость после действия гамма-излучения увеличилась на 25 %. Трихостатин А, напротив, повысил чувствительность мух к генотоксическому воздействию гамма-излучения, снизив выживаемость на 7-17 %.

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Продолжительность жизни, стрессоустойчивость, радиоустойчивость, гамма-излучение, трихостатин а, берберин, drosophila melanogaster

Короткий адрес: https://sciup.org/149143630

IDR: 149143630   |   DOI: 10.19110/1994-5655-2023-6-94-102

Список литературы Исследование геропротекторных и радиопротекторных эффектов берберина и трихостатина а на модели Drosophila melanogaster

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