Studying the humoral components stimulating osteogenesis

The composition of the components of blood plasma osteogenic fraction was studied in patients after bone injury (the main group, n = 10), as well as that of similarly isolated blood serum fraction of somatically normal donors (the reference group, n = 10). The content of proteins, protein fractions, hydroxyproline, sialic and uronic acids, and also that of insulin-like growth factor-1 was studied. The fraction of the main group has been found to consist of polypeptide- and carbohydrate-origin components and to contain more than 20-fold higher concentration of insulin-like growth factor-1 in comparison with the reference group fraction.