Research and assessment of the toxicity of nanodispesed aluminum oxide at repeated inhalation exposure

In this article present the results of research and assessment of toxicity of nanodispersed aluminum oxide at repeated inhalation exposure. It was established that the studied sample of aluminum oxide in terms of size and specific surface area is a nanomaterial. In the study of bioaccumulation, a significant increase in the concentration of aluminum in the lungs, brain, and blood of animals of the experimental group was revealed with respect to the control by 55.20, 5.96, and 1.62 times, respectively. In biochemical and hematological research methods, an increase in the level of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase, the number of segmented neutrophils and platelets was revealed with respect to the control in 1.78, 2.77, 1.56, 1.46, 1.44 and 1.22 times, respectively. Histological research methods in animals of the experimental group established: acute plethora of the liver and heart; subarachnoid hemorrhage of the brain; hyperplasia of lymphoid tissue, eosinophilia of infiltrate and hemorrhagic infarction of lungs. The results obtained must be taken into account when developing preventive measures for manufacturers and consumers of products containing aluminum oxide nanoparticles.