Trophic changes in the skeletal muscles of rats after pharmacotherapy with simvastatin in the modeling of critical ischemia of the lower extremities

Aims: To study the effect of simvastatin on trophic changes in skeletal muscles in experimental critical limb ischemia. Materials and methods: We investigated the effectiveness of pharmacotherapy for this disease with simvastatin (Simvastatin, Pharmstandard-leksredstva, Russia). Calf muscle ischemia was simulated in Wistar rats. Formed 4 groups of animals, 20 individuals: intact; falsely operated; with simulated critical ischemia without treatment (control group); with critical ischemia and simvastatin monotherapy (orally 1.71 mg / kg, daily, once for 28 days, experimental group). The level of blood microcirculation in the leg muscles was measured on the 21st and 28th days. At the same time, 10 animals were withdrawn from the experiment by anesthesia overdose and histological preparations of the leg muscles were prepared. Results: The level of regional blood flow significantly (p