The study of embryotoxic effect of titanium dioxide nanoperticles on rats

The widespread use of nanomaterials in various fields of human activity leads to a number of problems. It is well known that some nanomaterials may have an embryotoxic effect, having a direct effect on the fetus at penetrating through placental barrier. The purpose of this study is to evaluate, on the basis of the study of pre-implantational and post-implantational mortality and features of postnatal development, the embryotoxic properties of nanodispersed titanium dioxide (TiO2) when administered orally. It has been shown that oral administration of 50 mg/kg nanodispersed titanium dioxide to pregnant female rats from the 1st to 19th day of pregnancy has a pronounced embryotoxic effect, expressed in an increase in pre-implantational, post-implantational and total embryonic fetal mortality. The long-term effects of the antenatal effect of nanodispersed titanium dioxide on the development of the offspring of rats in the early postnatal period of ontogenesis were studied in the first 30 days of life...