The study locally irritating action of antioxidant 4,4'-bis (2,6-di-tert-butylphenol) on rabbits

The article is devoted to the study of the local irritating effect of a new feed antioxidant -4.4' - bis (2.6-ditretbutylphenol) on laboratory animals. For work, experimental animals were kept in individual cages with free access to food and water. The adaptation time before starting the experiment was at least 21 days. The local irritant effect of the antioxidant was evaluated in the experiment on rabbits. Oil solutions of the drug in doses of 2, 5 and 20 mg/kg of live weight were prepared for the test. It is experimentally established that the General condition of animals is satisfactory, the behavior corresponds to this type of animal, intensive motor movements, active movements in the cage, there are no convulsions, animal movements are coordinated, the reaction to sound, tactile and painful, sound stimuli is preserved. The coat is smooth, shiny, and the hair is firmly held in the hair bulb. The mucous membranes are pale pink in color, without hemorrhages or ulceration.