Исследование нейропротекторных свойств экстракта черноплодной рябины (Xsorbaronia mitschurinii) у линии Drosophila melanogaster, моделирующей болезнь Альцгеймера

Автор: Земская Н.В., Пакшина Н.Р., Платонова Е.Ю., Шапошников М.В., Москалев А.А.

Журнал: Известия Коми научного центра УрО РАН @izvestia-komisc

Статья в выпуске: 6 (64), 2023 года.

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Старение нередко сопровождается ухудшением когнитивных функций вплоть до развития нейродегенеративных заболеваний (сосудистая деменция, болезни Альцгеймера и Паркинсона). Биологически активные вещества, содержащиеся в плодах черноплодной рябины, ранее проявляли нейропротекторный потенциал по отношению к модельным организмам in vivo, поэтому нами была выдвинута гипотеза о возможном нейрогеропротекторном потенциале этанольного экстракта черноплодной рябины (×Sorbaronia mitschurinii) на Drosophila melanogaster со сверхэкспрессией предшественника бета-амилоида человека UAS-Aβ42, накопление которого в тканях мозга человека приводит к развитию болезни Альцгеймера. Исследовали влияние экстракта черноплодной рябины в концентрации 10 мг/мл на продолжительность жизни дрозофил с моделью болезни Альцгеймера. Установлено, что экстракт увеличивает медианную и максимальную продолжительность жизни самок до 11 %, а также медианную продолжительность жизни самцов на 2 %, но снижает их максимальную продолжительность жизни на 3 %. Данные результаты свидетельствуют о нейропротекторном эффекте экстракта черноплодной рябины.

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Черноплодная рябина, болезнь альцгеймера, продолжительность жизни, экстракт, drosophila melanogaster, sorbaronia mitschurinii

Короткий адрес: https://sciup.org/149143629

IDR: 149143629 | DOI: 10.19110/1994-5655-2023-6-86-93

Список литературы Исследование нейропротекторных свойств экстракта черноплодной рябины (Xsorbaronia mitschurinii) у линии Drosophila melanogaster, моделирующей болезнь Альцгеймера

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