The study of atrial natriuretic peptide in different types of arterial hypertension in experiment

By using methods of immunocytochemistry, transmission electron microscopy, light microscopy we studied the production of atrial natriuretic peptide in cardiac myocytes in rats in different types of hypertension. We suggested that high level of blood pressure does not influent on the accumulation and excretion of atrial natriuretic peptide without a combination of factors, including the increase in the area of connective tissue in the intercellular space, hypertrophy and changes in the ultrastructure of cardiomyocytes, and hypoxia in the vasorenal hypertension and in the remote post-reperfusion period in rats.