Research the influence of chemical factors risk on the reproductive health state at fertile age women

In work results of profound inspection of women having fetus congenital defects in the anamnesis and who are exposed by chemical reprotoxicants are presented. It is shown that in the conditions of chronic exposition caused by unsatisfactory quality of atmospheric air and water according to the content of lead, chrome, nickel, manganese, benzene, xylole, toluene, ethyl benzene, formaldehyde, the content in blood of exhibited women of these substances to 2,5 times exceeds the indicators of comparison group. The frequency of registration the chromosomes polymorphism increased to 2,3 times, to 11,6 times the frequency of increase the indicator 8-OHdG in urine (a marker of oxidizing stress at the level of DNA) at the exhibited group of women concerning group of comparison is established. Relationships of cause and effect of congenital defects, chromosomal imbalance, oxidizing damage of DNA with a dose of exposition and concentration of reprotoxicants in blood are proved. Recommendations of preventive actions taking into account validity of negative impact of reprotoxicants are made.