About the influence of the natural anthocyanin delphinidin on the lifespan of Drosophila melanogaster

Anthocyanins are vividly colored pigments that appear pink, red, blue, or violet and are dissolved in the vacuolar sap of the epidermal tissues of flowers, fruits, leaves, and stems. Delphinidin is one of the most common anthocyanins with the heroprotective potential. In this study, we examined the effect of delphinidin on the lifespan of both male and female Drosophila melanogaster. Our results showed that delphinidin concentration of 10 µM causes a statistically significant decrease in the median lifespan of male Drosophila melanogaster by 5% and an increase in median lifespan of females by 4 %. However, the mechanism of action of delphinidin on the organism is still understudied that limits our understanding of its heroprotective properties. In this context, studying the effects of delphinidin on the stress resistance, viability indicators, and the expression levels of aging-related genes in Drosophila melanogaster appears to be a promising direction. Such studies would discover the mechanisms of heroprotection and aging, as well as answer the question how natural anthocyanins like delphinidin can be used to improve human health and enlarge lifespan.