The history of juxtaglomerular apparatus of the kidney research

The history of juxtaglomerular apparatus of the kidney researching began in the end of 19th century from the renin discovery. This fact stimulated the opening of structures engaged synthesis of renin and study of the regulation and functional significance of renin and juxtaglomerular apparatus. These issues have been in the main resolved in the mid-20th century, which led to an understanding of the crucial role of the juxtaglomerular apparatus in the water and salt homeostasis preservation. In the early 80-ies of the 20th century the elucidation of the renin role in the pathogenesis of hypertension stimulated the study of its production mechanisms and intracellular mechanisms of its isolation. The examining of these issues continues now, and it is still far from the final solution.