History of the study of connective tissue dysplasia and its role in the development of postoperative hernias

Introduction. Postoperative hernias of the anterior abdominal wall present the most urgent problem in herniology today. Despite the use of modern techniques, the proportion of relapses is still high, ranging from 6,5 to 31 %. Many researchers suggest that one of the reasons for such a high recurrence rate is disorders in the structure of connective tissue and more and more attention is being paid to connective tissue dysplasia.The purpose of the study. To update information on the role of connective tissue dysplasia in the formation of hernias of the anterior abdominal wall.Materials and methods. A review of all available articles published on PubMed, Cochrane and Elibrary in Russian and English, containing the keywords: "collagenopathy", "dysplasia", "hernia", was conducted, as well as analyzed works that have a logical connection between the individual characteristics of connective tissue and the development of hernias of the anterior abdominal wall. A total of 125 literary sources were analyzed, 35 of the most relevant and cited are included in the list of references.Results. Currently, a significant amount of information has been accumulated on the role of an altered type I/III collagen ratio in the skin and fascia of the anterior abdominal wall in the development (recurrence) of hernias. The analysis of existing methods of phenotypic assessment of nonspecific connective tissue dysplasia has shown the advantage of the technique of N.G. Luzgina and V.A. Shkurupiya for patients with postoperative hernias.Conclusions. Further studies are needed to assess the effect of nonspecific connective tissue dysplasia on both the genesis of postoperative hernias and the results of surgical treatment using various modern techniques.